Hondurans protestors calling for the exit of President Juan Orlando Hernandez turned violent as police used tear gas to disperse hundreds of demonstrators in the capital.
Protesters blocked roads with burning tires. Windows were broken in downtown businesses.
Government critics have been emboldened by the conviction of Hernandez's younger brother on drug trafficking charges in a New York court last month after a trial during which witnesses implicated the president in the drug enterprise.
The president has strongly denied the claims, which included drug traffickers testifying that they gave $1.5 million to Hernandez's various political campaigns in exchange for protection from security forces.
Salvador Nasralla, a television personality who finished second to Hernandez in the last election, leads a coalition calling for the president to step down. They have promised civil disobedience until Hernandez is gone and threatened a national strike but haven't set a date.